The Coronaviruses’ Spike protein assists virus entry through host cells. The existence of Spike (S) protein is a defining feature of all coronaviruses, which are linked to severe acute respiratory syndrome (SARS). Other types of COVID-19 – which originated in the United Kingdom, South Africa, and Brazil, respectively – are more transmissible and virulent, inclusive of B.1.1.7, B.1.351, and P.1. Since then, several mutations have occurred in the SARS-CoV-2 genome causing the incidence of other variants. In the first 6 months of the pandemic, the novel Coronavirus brought about the demise of about one million people and wreaked havoc on the global economy and social order. Almost 20% of COVID-19 patients require hospitalization, and nearly 5% could get into critical condition. The majority of individuals infected by SARS-CoV-2 are asymptomatic or have mild symptoms. Apart from the commonly known respiratory symptoms, COVID-19 could cause cardiovascular, neurological, gastrointestinal, and renal complications and involvements, among others. 2019-novel Coronavirus (nowadays known as SARS-CoV-2) is a human beta-coronavirus responsible for COVID-19, the most sustainable pandemic catastrophe in the last century. In December 2019, SARS-CoV-2 was discovered following the identification of strange pneumonia in a group of patients in Wuhan, China, Mainland. Finally, the differences of various vaccines on thrombotic events, WHO recommendations for VITT treatment, and blood clots statics are discussed.Ĭoronaviruses are numerous enveloped viruses, and their genetic material is made up of ss-RNA. Various methods for producing the COVID-19 vaccines are analyzed, along with their possible pros and cons as well as common and rare side effects, especially VITT and blood clots. By evaluating rigorous studies published on this subject, the present article is aimed at identifying the association between blood clot incidence and COVID-19 vaccination. In some countries, such concerns have even resulted in the temporary or permanent discontinuation or abandonment of the application of some vaccines (especially AstraZeneca and Janssen). One of the causes for concern among the researchers, physicians, and generally the whole community from the onset of vaccination has been the adverse effects (specifically blood clots) that may be observed after the injection of the COVID-19 vaccine. The critical issue now is to concentrate on protecting individuals against illness through immunization. In effect, vaccines have been proffered as a viable option. Several therapeutic strategies for COVID-19 management have been offered nonetheless, none of them seems to be sufficiently beneficial. SARS-CoV-2 pandemic is one of the most critical pandemics during human civilization.
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